Ontario public health measures
COVID-19 Info | Information sur la COVID-19 | COVID-19 Vaccine Vaccine Receipt | COVID-19 Self-Assessment

Middlesex-London Health Unit

🔍Search
🔍
Home
Inner Nav

Hepatitis B Vaccine Schedule For Infant Born To Hepatitis B Carrier Mothers 

TIMING 

REQUIREMENT

DOSE

ADMINISTERED BY

Within 12 hours of birth

 

Hepatitis B Immune Globulin

0.5 ml IM 

hospital

Within 12 hours of birth

 

Engerix or Recombivax- HB

0.5 ml IM

hospital

1 month of age

 

Engerix or Recombivax- HB

0.5 ml IM

primary care physician 

6 months of age

 

Engerix or Recombivax- HB

0.5 ml IM

primary care physician 

9 - 15 months of age

Post-vaccination serology

(HBsAg and anti-HBs)

 

primary care physician

 

 

  •  Pre-term infants, except those less than 2000 grams, should follow the above schedule.  Pre-term infants less than 2000 grams require an additional dose of hepatitis B vaccine. A schedule of 0, 1, 2, and 6 months is recommended.
  • The initial hepatitis B vaccine and hepatitis B immune globulin can be given at the same time but at separate sites.
  • The 6-month hepatitis B vaccine can be administered at the same time as the third Pediacel (and Prevnar for high risk infants) injections but at a different site.

Post Vaccination Serology

  • The tests that should be completed in this serology screen are hepatitis B surface antigen (HBsAg) and antibody to hepatitis B surface antigen (anti-HBs or HBsAb).
  • If HBsAg is positive, the child is likely a carrier and prophylaxis was unsuccessful. 
  •  If the child is positive for anti-HBs (≥ 10 IU/L) and negative for HBsAg, the prophylaxis successfully prevented hepatitis B.
  • If the infant’s serology is negative for both HBsAg and anti-HBs (anti-HBs < 10 IU/L), the infant is considered a non-responder. A series of three additional doses of hepatitis B vaccine should be started immediately and post-vaccination serology completed at least one month after the completion of this second vaccination series.

For more information call the Middlesex-London Health Unit, Oral Health, Communicable Disease and Sexual Health Services Division at 519 663-5317 ext. 2330.

 
Date of creation: November 12, 2012
Last modified on: November 5, 2015